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KMID : 0043320150380101752
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Archives of Pharmacal Research
2015 Volume.38 No. 10 p.1752 ~ p.1760
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Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes
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Park Ji-Hae
Mohamed Mohamed Antar Aziz
Jung Ye-Jin
Shrestha Sabina
Lee Tae-Hoon
Lee Chang-Ho
Han Dae-seok
Kim Ji-Young
Baek Nam-In
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Abstract
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Four sesquiterpenes were isolated from the rhizome of Curcuma xanthorrhiza Roxb.: furanodiene (1), germacrone (2), furanodienone (3), and 13-hydroxygermacrone (4). Importantly, this was the first time compounds 1 and 4 were isolated from this plant. The chemical structures of these compounds were determined using 1D- and 2D-nuclear magnetic resonance, infrared spectroscopy, and electron ionization mass spectrometry analyses. Among the isolated compounds, compounds 2 and 4 inhibited UVB-induced upregulation of the mRNA and protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes (HaCaT). Moreover, this upregulation occurred in a dose-dependent manner over the range of 1?10 μM for each compound.
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KEYWORD
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Curcuma xanthorrhiza, Germacrane, HaCaT, MMPs, NMR, UVB
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